Endocrine Abstracts

Introduction: Autoimmune diseases have a high prevalence in the general population, and AITD is one of the most common representatives. Although IgE is the main regulator of allergic reactions, there is evidence to suggest a link between AITD and allergic diseases, demonstrated by the example of chronic spontaneous urticaria (CSU).Aims: For this research, we have set the following goals: to determine whether there is an association between the serum leve...

Thyroid C-cells, as a second type of endocrine cell population within thyroid, produce and secrete peptide hormone calcitonin (CT). This hypocalcemic hormone acts as an inhibitor of bone resorption. The aging is a complex process that alters various cellular functions. Therefore, the aim of this study was to examine the aging-related changes in the structure and function of CT-producing thyroid C-cells in male Wistar rats, using histomorphometric, ultrastructural and biochemic...

Background: Hypopituitarism can be expressed throughout many symptoms and can stay unrecognized for a long time. Xanthogranulomas are extremely rare in sellar region, with prevalence of ~0.6% in reported pituitary tumours and are presented with visual disturbance, hyperprolactinemia, diabetes insipidus and/or hypopituitarism. Its ethiopathogenesis is still not certain, but it can be of primary or systemic cause. It’s almost always diagnosed postoperatively and has good ou...

Calcitonin (CT) is a hypocalcemic hormone produced by thyroid C-cells that acts as an bone antiresorptive agent. The other endocrine cell population in thyroid, called follicular cells produce thyroid hormones (TH) which also affect bone turnover. In this study, we evaluated the effects of salmon CT administration on structure and function of both CT and TH producing thyroid cells as well as trabecular bone microarchitecture in orchidectomized (Orx) middle-aged rats. Fifteen-m...

Aging process is accompanied by structural and functional changes in different organs including bone and muscle tissues. Between these tissues there is a mutual interaction mediated by endocrine factors such as the peptide hormone osteocalcin, produced by osteoblasts. Since the skeletal muscles is composed of two basic fiber types, slow-twitch (type I) and fast-twitch (type II), the aim of this study was to examine the age-related changes in rat fast-twitch skeletal muscle fib...