Endocrine Abstracts

Introduction: Prolactin secreting pituitary adenoma represents the most common functioning pituitary neoplasm with a clinical picture that includes amenorrhea, galactorrhea and infertility. Tumor size may vary from microadenomas amendable to medical therapy with dopamine agonists to macroadenomas with difficult management. Complications are usually related to tumor size and most frequently include hypogonadism alone or associated with other pituitary deficiencies, visual field...

Introduction: Medullary thyroid cancer (MTC) is a neuroendocrine tumor of the parafollicular or C cells of the thyroid gland. While thyroid cancer is increasingly common worldwide, MTC still has a low incidence. We present a case of a seventy-one-years-old woman who presented in our unit after an axillary adenopathy biopsy which tested sparsely positive for KeratinPan, CK7, CEA, TTF1, Chromogranin, Snaptophysin and calcitonin, focal positive for EMA, PAX8, Ki67 30%. Also multi...

Introduction: Hypoglycemia is the most frequent metabolic complication observed in patients with type 2 diabetes mellitus (T2DM). Moreover, rare insulinomas are the most common cause of endogenous hyperinsulinemic hypoglycemia in adults. The coincidence of insulinoma in a patient with pre-existing T2DM is an extremely rare condition and there are few case reports in the medical literature.Case report: A 76-year-old woman diagnosed with T2DM 6 years ago, ...

Background: Primary hyperparathyroidism (PHPT) is nowadays an asymptomatic disease characterized by mild hypercalcemia and elevated parathormone (PTH) levels. PHPT is caused by parathyroid adenoma in 80–85% of patiens, up to 20% are located ectopically and therefore an ultrasound investigation is not helpful. SPECT sestamibi or tetrofosmin scintigraphy of the neck and thorax is considered to be the optimal method for the evaluation of ectopic parathyroid adenoma.<p cl...

Background: Head trauma of sufficient severity, particularly causing fracture to the skull base, can cause deficient secretion of anterior pituitary hormones and vasopressin. Severe hypopituitarism and diabetes insipidus (DI) are common post-traumatic events but they can recover 3 and 12 months afterwards.Objective: To report a case of a woman with post-traumatic hypopituitarism and DI after car accident.Case report: A 31 year old ...

BackgroundCushing syndrome (CS) is caused by prolonged exposure to elevated cortisol levels and it’s classified as either ACTH-dependent or ACTH independent CS. The most common form of endogenous ACTH CS is Cushing disease (CD); ACTH-independent CS is caused by various adrenal abnormalities. First-line therapy in CS is the resection of the underlying tumor in all cases. After surgical cure of CS, most patients develop transient secondary adrenal ins...

Introduction: Adrenocortical carcinoma is a rare tumour, with an annual incidence of 1 to 2 case per million. Hypercortisolism constitutes the predominant clinical manifestation in patients with hormone excess, presenting in 50% to 80% of all adrenocortical carcinomas. Non-functioning tumors are even rarer, comprising only 20% of adrenal carcinomas in the largest reported series. Conversely, Addison’s disease is also an infrequent disorder, with estimated incidence rates ...

Objective: Polycystic ovary syndrome (PCOS) phenotypes, generated by the possible combinations of the three Rotterdam diagnostic criteria, show a different scale of metabolic risk among PCOS women, being greatest in the classic subgroup, followed by the ovulatory and normoandrogenic phenotype. Aldosterone is an important cardiovascular risk factor. Previous studies reported increased levels of aldosterone in PCOS women, suggesting a possible role in the development of some car...

Objective: Analyse the features of first patients treated with PCSK9 inhibitors in a specific Familial dyslipidemia Unit and the effects on lipid profile in first months of treatment.Material and methods: Data from patients with heterozygous familial hypercholesterolemia treated with PCSK9 inhibitors were reviewed. Clinical data, physical examination and analytical data were collected at baseline, one month and 3 months.Results: Da...

Introduction: Acute pancreatitis induced by hypertriglyceridemia is a severe condition and its management is complicated.Case report: We present a case of severe acute pancreatitis induced by hypertriglyceridemia secondary to lipoprotein lipase -LPL- deficiency (188 Gly-Glu mutation, LPL undetectable activity) in a pregnant patient with gestational diabetes.The patient was sent to our Lipid Unit in the 13th gestation’ week. Th...