Endocrine Abstracts

Graves’ disease (GD) is an autoimmune disease that can affect other tissues in addition to the thyroid gland. Depending on the intensity of the immune response, in addition to hyperthyroidism, orbitopathy, dermatopathy and acropachy can also occur. Extrathyroidal manifestations of GD are most often the result of a more pronounced immune response. Thyroid dermatopathy (TD) is a rare extrathyroidal manifestation of GD, almost always associated with Graves’ orbitopathy ...

Background: Thyroid hormones have regulatory effect on serotonin and noradrenaline and thyroid dysfunction is closely linked to some mental disorders. Besides depression and anxiety, and increased risk for suicide is demonstrated in patients with Graves’ disease (GD).The aim: of our research was to determine the symptomatology of depression in patients with hyperthyroidism and Graves’ orbitopathy (GO) and compare it with hyperthyroid patients w...

Citrus flavanone naringenin (NAR) is a potent antioxidant with ability to change pituitary-thyroid function. NAR increases concentration of thyroid-stimulating hormone (TSH) in serum by increasing Sirtuin1 expression in the pituitary thyrotrophs and improves thyroid hormonogenesis capacity in old-aged rats. Thyroid hormone production is followed by generation of large quantities of reactive oxygen species (ROS) which are essential for iodine organification. A master regulator ...

Serum calcitonin (CT) screening of thyroid nodules is a highly sensitive test for early diagnosis of medullary thyroid carcinoma (MTC) and is used for initial diagnosis and post-surgical follow-up. MTC is neuroendocrine tumor derived from parafollicular C cells which produce calcitonin. It is a rare tumor, accounting for 5-10% of all thyroid carcinomas, with a favorable prognosis if diagnosed early. A 74-year-old patient was referred to our clinic due to elevated basal CT leve...

Soy isoflavone daidzein exerts some beneficial effects in different ageing-related, chronic diseases and may represent a promising alternative to classical estrogenization of the prostate cancer suffering subjects. The aim of this study was to examine the effects of daidzein on the adrenocortical vascular network and hormonal output in a rat model of the mild andropause. Adult (3 months old) Wistar rats were divided into sham-operated (SO; n=7), orchi...