Endocrine Abstracts

Background: Prolactinomas are the most common functioning pituitary tumours, accounting for 40% of all pituitary adenomas. Prolactinomas may enlarge in pregnancy, the management of which may prove challenging. Case Presentation: A 23 year old lady was referred to the endocrine clinic with secondary amenorrhoea and bifrontal headaches in 2012. Biochemical tests on referral revealed: FT4- 5.8 pmol/l, TSH-1.1 mU/l, Prolactin-4432 mIU/l, LH- 4.8 IU/l, FSH- 4...

History: A 52-year-old woman was referred by her GP for colonoscopy in view of 7 months” history of unexplained weight loss of nearly 2.5 stones, constipation and recently detected normocytic anaemia. Her past medical history was unremarkable except for bronchial asthma that was managed with albuterol. However, on the day of the scheduled colonoscopy, she was noted to be hypotensive (BP- 63/38 mm Hg, heart rate 93 bpm) and was hence admitted for fluid resuscitation. Follo...

Section 1: Case history: A 46-year-old woman was referred to the Endocrinology clinic for evaluation of persistently elevated parathyroid hormone levels despite correction of previous vitamin D deficiency. She had a history of calcific tendinitis of the left shoulder and iris pigment dispersion syndrome. Notably, her mother had undergone two parathyroid surgeries for primary hyperparathyroidism with removal of three parathyroid glands, revealing multiple parathyroid adenomas a...

Multiple Endocrine Neoplasia Type 1(MEN1) syndrome is commonly associated with the three ’P’s-pituitary, parathyroid and pancreatic lesions. However, increasingly, thoracic neuroendocrine tumours (NETs) are being recognised with the syndrome. We present a case of MEN1 syndrome who primarily presented with a lung carcinoid tumour. A 31-year-old lady with without a significant past medical history presented with 2-month history of a persistent cough. ...

Case History: A 57 year old male, who was known to have primary hyperparathyroidism was admitted to hospital due to hypercalcaemia on routine blood tests (adjusted S. calcium- 3.44 mmol/l.) He had no symptoms due to hypercalcaemia. This was his 5th admission since the diagnosis 18 months ago, each admission requiring treatment with IV fluids and IV bisphosphonates. SESTAMIBI and ultrasound scans of the thyroid and parathyroids had previously localised a likely right inferior p...

Introduction: Vitamin D deficiency is known to cause adverse outcomes in pregnancy and has shown to have an association with Gestational Diabetes Mellitus (GDM)Aim: To evaluate the relationship between GDM and Vitamin DMaterials and Methods: In a retrospective study we explored the Vitamin D levels (Sufficient >50nmol/l - G1, Insufficient 25-50nmol/l - G2, Deficient <25nmol/l - G3), GTT results, diabetes status and pregnanc...

Background: Hyponatraemia is the most common electrolyte abnormality encountered in hospitals and has been independently associated with increased morbidity and mortality1. An appropriate work-up with guideline-based investigations and management is, therefore, crucial to allow accurate diagnosis and optimisation of patient care.Case Presentation: A 49-year-old with no significant past medical history presented with 2 weeks of persistent nause...

Background: Metastatic disease is common in bone, with the majority occurring in the spine, pelvis, and long bones such as the femur and humerus. Acrometastasis, a term used to describe malignant spread distal to the elbow and knee, is a pattern less commonly seen. Its rarity often leads to delayed diagnosis; the condition may be confused with more common conditions such as inflammatory arthritis and Charcot neuroarthropathy, the latter especially in particular in patients wit...

Background: The importance of vitamin D supplementation in pregnancy is well known. Hypovitaminosis D is associated with adverse maternal and foetal outcomes such as pre-eclampsia, gestational diabetes mellitus, bacterial vaginosis, increased incidence of caesarean section delivery, intra-uterine growth restriction and reduced bone and muscle mass in childhood. The recommendations for vitamin D supplementation vary widely, with NICE guidelines suggesting a daily replacement do...

Background: The published data on the natural history of (presumed) non-functioning pituitary microadenomas (micro-NFAs) is possibly compromised by small sample sizes, short follow-up and inclusion of cases with other pathologies in the analyses.Objective: To clarify the long-term outcomes of micro-NFAs in a large cohort of patients.Methods: We conducted a multi-centre, retrospective, cohort study involving 22 UK endocrine departme...