ea0041ep195 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016
Schulte Dominik M
, van der Valk Fleur M
, Meiler Svenja
, Tang Jun
, Zheng Kang He
, van den Bossche Jan
, Seijkens Tom
, Laudes Matthias
, de Winther Menno
, Lutgens Esther
, Alaarg Amr
, Metselaar Josbert M
, Dallinga-Thie Geesje M
, Mulder Willem J M
, Stroes Erik S G
, Hamers Anouk A J
Introduction: Patients with a Cushing syndrome a glucocorticoid driven diseasehave a high risk for cardiovascular events, mainly due to atherosclerosis. Atherosclerosis is a lipid-driven inflammatory disease, for which novel anti-inflammatory strategies like glucocorticoids are under evaluation. Thus, the impact of glucocorticoids on atherosclerosis seems to be ambiguous: pro- or anti-inflammatory. To avoid systemic glucocorticoid side effects contributing to athe...