Endocrine Abstracts

Introduction: Acute intermittent porphyria (AIP) is an autosomal dominant disorder resulting from partial deficiency of the haeme biosynthetic enzyme porphobilinogen deaminase.Case report: A 17-year-old female presented with progressive abdominal pain. She had history of recurrent abdominal pain and darkening in urine colour. She was on lansoprazol and metaclopramide, initiated 2 days earlier. She did not have additional personal or relevant family histo...

Introduction: Hypophysitis is a rare pituitary inflammation due to primary and secondary causes. Xanthomatous hypophysitis is the rarest subtype and described with lipid-laden cystic areas, transparent cytoplasmic and lipid-laden histiocytes and foamy (xanthomatous) histiocytes. Although the etiology of xanthomatous hypophysitis is not clearly known, it has been suggested to develop as a result of autoimmune cause or inflammatory process of infiltration of cyst components from...

Objective: Neurosteroids, a unique hormone group, are recognized for their impact on cognitive processes. The primary objective is to assess the correlation between cognitive function and NS levels in cases of Cushing’s disease and a control group of nonfunctional pituitary adenoma (NFPA).Design: The study comprised 26 individuals diagnosed with Cushing’s disease (CDG), while a control group (CG) consisted of 14 age-gender matched participants ...

Introduction: Acromegaly is a chronic disorder characterized by chronic growth hormone (GH) excess. In most of cases, GH hypersecretion is derived from somatotroph cell tumors. Survivin is a member of apoptosis protein family, which was recently showed to be expressed in different benign and malignant human tumors. A number of studies showed overexpression of survivin in pituitary adenomas. This study is intended to determine circulating levels of survivin in patients with acr...

Introduction: We aimed to determine changes in geriatric assessment of cases with acromegaly.Methods: 26 elderly cases with acromegaly (controlled/uncontrolled: 15/11, F/M: 17/9) were included. 20 age, gender and BMI matched cases without acromegaly composed control group (CG) (F/M: 10/10). Presence of concomitant diseases and educational level were not different between the groups. Cognitive functions were evaluated with Mini Mental State Exam (MMSE), a...

Objective: Even with advancements in diagnostic techniques, acromegaly continues to be diagnosed late. This study aimed to employ deep learning methods to automatically identify acromegaly disease from images of faces, hands, and feet to enhance the efficiency of disease detection.Design: Cross-sectionaly single-center study with deep learningMethods: The study included 71 acromegaly patients and 65 healthy controls. All patients h...