ea0021p123 | Cytokines and growth factors | SFEBES2009
Otsuka Fumio
, Yamanaka Ryutaro
, Nakamura Kazufumi
, Yamashita Misuzu
, Takeda Masaya
, Suzuki Jiro
, Miyoshi Tomoko
, Inagaki Kenichi
, Makino Hirofumi
Primary arterial hypertension (PAH) is a life-threatening disease that has prevalence of 1 to 2 occurrences per one million individuals. This disease is characterized by excessive proliferation of vascular endothelium and smooth muscle cells, causing thickening the walls of pulmonary arterioles. Recent studies have uncovered a link between familial and idiopathic PAH to BMPRII mutations. The pathology of PAH is characterized by the remodeling of pulmonary arteries due to pulmo...