Endocrine Abstracts

Thyroid C-cells, as a second type of endocrine cell population within thyroid, produce and secrete peptide hormone calcitonin (CT). This hypocalcemic hormone acts as an inhibitor of bone resorption. The aging is a complex process that alters various cellular functions. Therefore, the aim of this study was to examine the aging-related changes in the structure and function of CT-producing thyroid C-cells in male Wistar rats, using histomorphometric, ultrastructural and biochemic...

Calcitonin (CT) is a hypocalcemic hormone produced by thyroid C-cells that acts as an bone antiresorptive agent. The other endocrine cell population in thyroid, called follicular cells produce thyroid hormones (TH) which also affect bone turnover. In this study, we evaluated the effects of salmon CT administration on structure and function of both CT and TH producing thyroid cells as well as trabecular bone microarchitecture in orchidectomized (Orx) middle-aged rats. Fifteen-m...

Aging process is accompanied by structural and functional changes in different organs including bone and muscle tissues. Between these tissues there is a mutual interaction mediated by endocrine factors such as the peptide hormone osteocalcin, produced by osteoblasts. Since the skeletal muscles is composed of two basic fiber types, slow-twitch (type I) and fast-twitch (type II), the aim of this study was to examine the age-related changes in rat fast-twitch skeletal muscle fib...