ea0090p715 | Reproductive and Developmental Endocrinology | ECE2023
Alexander Emma
, Faruqi Duaa
, Farquhar Robert
, Unadkat Ayesha
, Ng Yin Kyla
, Kokotsis Vasilis
, Howard Sasha
Background and aims: Hypogonadotropic hypogonadism is characterised by inadequate secretion of gonadotropins (luteinising hormone (LH) and follicle-stimulating hormone (FSH)) leading to absent, partial or arrested puberty. In males, classical treatment with testosterone promotes virilisation but does not facilitate testicular growth or spermatogenesis. Conversely, treatment with gonadotropins or gonadotropin-releasing hormone (GnRH) stimulates Sertoli and Leydig cells directly...