Endocrine Abstracts

Aim: To explore if MR-proANP is associated with cardio-metabolic risk factors in patients with med type 2 diabetes mellitus (T2D) and non-diabetic controls.Methods: MR-proANP was analyzed in 761 middle-aged (54–66years) patients with type 2 diabetes and 184 non-diabetic controls and related cardio-metabolic conventional risk factors as age, sex, previous cardiovascular diseases (atrial fibrillation, myocardial infraction), glucose, LDL cholesterol, ...

Background: We aim to test whether plasma copeptin (copeptin), the C-terminal fragment of vasopressin, has predictive value of cardiovascular events in patients with type 2 diabetes without previous cardiovascular disease who were treated in primary care.Methods: We measured copeptin in 697 patients who participated in the epidemiological study CARDIPP (Cardiovascular Risk Factors in Patients with Diabetes – a Prospective Study in Primary Care; Clin...

Background: Individuals with diabetes are at higher risk for developing arterial disorders. The toe-brachial index (TBI) is associated with peripheral vascular disease, and aortic pulse-wave velocity (aPWV) is currently the gold standard for assessing arterial stiffness. High concentrations of plasma arginine vasopressin (AVP) preferentially stimulate V1a receptors, which affect the vascular bed and may contribute to cardiovascular (CV) complications. Copeptin, a more stable p...

Background: Earlier identification of diabetes patients at high risk of developing cardiovascular complication will help develop new therapeutic targets for the prevention of secondary diseases and death.Objectives: We aim to test the predictive value of toe brachial index (TBI) as a risk marker of major adverse cardiovascular events (MACE) in patients with type 2 diabetes.Methods: TBI was measured in 741 patients with type 2 diabe...