Endocrine Abstracts

Patients with type 2 diabetes have an increased risk of premature coronary heart disease (CHD). One of the underlying reasons for this increased risk is atherogenic dyslipidemia. Current management strategies focus on the initial use of statin or fibrate therapy (the latter approach indicated in patients with pronounced hypertriglyceridemia).American Diabetes Association recognizes serum triglycerides as a surrogate for atherogenic triglyceride-rich lipo...

The class of endocrine disrupting chemicals (EDCs) is comprised of both naturally occurring and man-made compounds which are structurally similar or distinct to estrogen, and can interfere with the actions of an endogenous steroid hormone via estrogen receptors (ERs). Octylphenol (OP) is alkyl phenol chemical, which is considered to be a low-level endocrine disruptor owing to its tendency to mimic estrogen. It has been reported that triclosan can cause endocrine disruption and...

Benzophenones are organic chemicals widely used as stabilizers to UV light irradiation in plastic surface coatings and food packaging. They have been known that their derivatives appear to have cytotoxic effects. 2-Hydroxy-4-methoxybenzophenone (Benzophenone-3, BP-3) and its metabolite, 2,4-dihydroxybenzophenone (Benzophenone-1, BP-1), are used mostly in the formulation of nail polishes, enamels, bath products, sunscreens and skin care products. In this study, the estrogenic e...

Adrenal masses are common incidental radiological findings. It has been estimated that as many as 10–20% of patients with essential hypertension may suffer from undiagnosed primary aldosteronism (PA). In patients who have both adrenal incidentaloma, which the functioning one must be identified. We report a case where an unilateral PA was detected on 18F-fluorodexoyglucose (FDG)-positron emission tomography (PET), and comfirmed by adrenal venous sampling.<p ...

Background: True cyclical Cushing's syndrome is rare and usually due to an ACTH-secreting corticotrophinoma. We describe a man with cyclical Cushing's syndrome of 15 years duration who had unexpected pituitary immunohistopathology.Clinical details: A 22-year-old man presented in 1986 with clinical features of Cushing's syndrome & urinary free cortisols up to 1800 nmol/24h, but normal low-dose DXM suppression, & normal pituitary and adrenals on CT. He was then lost ...

Background: Since receiving its UK licence in 1994, cabergoline [CAB] has become the dopamine agonist of choice for the management of hyperprolactinaemia in most UK endocrine units. Aim: To review the outcomes for the mother and neonate when CAB is taken during conception and into early gestation. Method: Retrospective review of Aberdeen casenotes from all hyperprolactinaemic women of childbearing age on CAB therapy and those of their live born infants. Results: Twenty women w...