ea0027p15 | (1) | BSPED2011
El-Khairi Ranna
, Parnaik Rahul
, Lin Lin
, Dattani Mehul
, Conway Gerard
, Achermann John
Background: The Lin28 family of proteins are emerging as important regulators of microRNAs in endocrine systems. Lin28a influences primordial germ cell development in mice, and overexpression of Lin28a in transgenic mice has recently been shown to influence body size, timing of puberty and litter size. The related protein LIN28B is associated with age at menarche and stature in several independent genome-wide association studies in humans.A...