ea0029p31 | Adrenal cortex | ICEECE2012
Reimondo G.
, Giachino D.
, Micossi I.
, Berchialla P.
, Varacalli S.
, Allasino B.
, Pia A.
, Laino F.
, Peraga G.
, Cosio P.
, Sciolla C.
, De Marchi M.
, Terzolo M.
The effects of glucocorticoids are mediated by the glucocorticoid receptors (GR) and some single nucleotide polymorphisms (SNPs) have been associated to enhanced sensitivity (N363S, BclI) or reduced sensitivity (ER22/23EK) to glucocorticoids.Aim of the present study was: 1) to assess the frequency of N363S, BclI and ER22/23EK in 46 patients with Cushings syndrome (CS) and 73 patients with adrenal incidentaloma (AI) compared to 186 healthy subjects;...