ea0028p218 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012
Lu Buyu
, Markovic D.
, Pessin Jeff
, Lehnert Hendric
, Grammatopoulos Dimitris
In addition to well established role in coordinating mammalian adaptive responses to stressful stimuli, the family of stress peptides that includes corticotropin releasing hormone (CRH) and urocortins (Ucns) are emerging as important regulators of the homeostatic mechanisms regulating energy balance and metabolism. CRH acting through specific G-protein coupled receptors, CRH-R1 and R2 can target multiple peripheral tissues such as skeletal muscle and adipose tissue...