Endocrine Abstracts

Background: If the laboratory results are not compatible with the patient’s clinical symptoms, the presence of possible test interference should be considered. Despite the excellent quality of immunoassays, it is currently estimated that they may be susceptible to several types of interference that may lead to patient misdiagnosis.Case report: In our case report we present a 71-year-old woman with confirmation of macro-adrenocorticotropic hormone (m...

Introduction: Teriparatide (TPTD) is a recombinant aminoterminal fragment (1–34) of the human parathyroid hormone (PTH), which has a predominantly stimulating effect on bone formation. We report results of an 18-month prospective multicenter study with daily s.c. application of 20 μg of teriparatide in 85 elderly women with severe osteoporosis, the efficacy, safety and compliance of the treatment.Outcomes: The primary outcomes were defined as c...

Pseudohypoparathyroidism (PHP) is a group of rare hereditary diseases caused by tissue resistance to parathyroid hormone (PTH), there are two main types I and II. Type I is divided into subtypes. The authors present a case of PHP Ib, with hypocalcemia (level of total calcium 1.41 mmol/l), accidentally detected at childbirth. After the unsuccessful treatment of hypocalcemia, the etiology was considered, but the confirmation of the diagnosis were not adequately tightened. Due to...

Background: Endogenous Cushing’s syndrome (CS) comprises the symptoms and signs associated with prolonged exposition to inappropriately high levels of glucocorticoids produced by adrenal cortex. Epidemiological studies reported an incidence of 0.7–2.4 cases per 1 million inhabitants per year. Late-night salivary cortisol (LNSC) is one of three currently recommended initial screening tests for CS. The advantages of LNSC are nonivasive specimen collection and minimal i...

Background: Although the excision of ACTH-producing tumors or adrenal tumors is the principal treatment for Cushing syndrome (CS), pharmacologic treatment has a well-established role. Among various medical agents, ketoconazole (KTZ) has inhibitory effect over 17,20 desmolase, 17α-hydroxylase, 11β-hydroxylase, and 16α- and 18-hydroxylase; moreover, it also inhibits ACTH production and cellular growth, partly because of apoptosis induction.C...

Background: The presence of functional ACTH receptors (MC2R) on osteoblasts and fact, that their activation lead to the proliferation of osteoblasts is consistent with the presence of receptors for another anterior pituitary hormones (FSH and TSH) on bone cells. Does ACTH directly regulate bone? Is it possible, that this is another hormone of a novel regulatory axis, pituitary-bone axis, in which hormones bypass traditional endocrine targets to regulate bone mass directly? Sup...

Authors present a 35-year-old female with thyroid orbitopathy (EO) associated with Graves disease. After initial antithyroid therapy, thyroidectomy was indicated and performed uneventenfully. Due to persisting severe clinically active EO, thyroablative therapy with 131I was performed three years later, intravenous pulse of methylprednisolone was given and consecutive oral therapy with prednisone initiated. This caused weight gain (from 63 to 80 kg) and iatrogenic Cu...

Backrgound: Coexistent gastrointestinal pathology might alter hydrocortisone (HCT) and levothyroxine (LT4) absorption and gut transit times.Aims: To screen patients with autoimmune Addison disease for the presence of serological markers of autoimmune gastrointestinal disorders, to compare doses of HCT and LT4 in patients with positive autoantibodies to those of patients without signs of autoimmune gastroenteropathy.Subjects and met...

Background: Newborn screening is the only systematic work-up of thyroid disorders in Slovakia with unambigously proven positivities. There is wide discussion regarding the screening of thyreopathies in specific risk groups such as pregnant women.Aims: To study the gynaecologist and endocrinologist co-operation in screening pregnant patients from region of Liptov and Orava for autoimmune thyroiditis.Subjects and methods: The partici...

Introduction: Pituitary ACTH-dependent Cushing´s disease and acromegaly are rare conditions. Pituitary adenomas co-secreting GH and ACTH are even more unusual.Case report: A 29-year-old patient, mother of three children, long-term follow-up by an endocrinologist for a thyroid struma without an autoimmune basis, was sent in April 2023 for further examination for detection of hypercortisolemia and insufficient suppressibility in the overnight 1 mg dex...