ea0099rc12.3 | Rapid Communications 12: Diabetes, Obesity, Metabolism and Nutrition | Part II | ECE2024
Robino Jacob
, Plekhanov Alexander
, Zhu Qingzhang
, Jensen Michael
, Scherer Philipp
, Roberts Charles
, Varlamov Oleg
The pathological expansion of white adipose tissue (WAT) in obesity involves adipocyte hypertrophy accompanied by expansion of collagen-rich pericellular extracellular matrix (ECM) and the development of crown-like structures (CLS). Traditionally, WAT morphology is assessed through immunohistochemical analysis of WAT sections. However, manual analysis of large histological sections is time-consuming, and available digital tools for analyzing adipocyte size and pericellular ECM...