Endocrine Abstracts

Extracellular proteolytic cleavage of insulin receptor (IR) and the generation of soluble insulin receptor (sIR) is a response of the liver and fat associated with physiological conditions and metabolic alterations mainly related to hyperinsulinemia. However, cleavage of this receptor has not been analyzed in skeletal muscle, a central tissue in insulin-mediated glucose homeostasis. This study aimed to analyze the insulin receptor subunits in the gastrocnemius and soleus muscl...