Endocrine Abstracts

The control of acromegaly with drug therapy (DT) by fg-SRLs is achieved only in 40–50% of cases, due to the heterogeneous composition of somatotrophic tumors. In order to optimize DT stratification of clinical and immunophenotypic biomarkers which make it possible to predict the long-term effectiveness of fg-SRLs at early stages is required. The aim of the work was to assess the informativeness of pharmacotherapeutic testing (% of decrease of IGF-1 level after 3 and 6 mon...

Introduction: Acromegaly – a serious debilitating disease resulting in decreased quality and length of life. Due to the late nature of the diagnosis, the lack of prospects for a surgical or non-radical adenomectomy leads to a somatostatin analogues (SA) treatment as primary or secondary therapy, which is a long-term, sometimes lifelong. Therefore, the question of tolerability and prevention of life-threatening complications for these patients is very important. Since the ...

Taking into account heterogeneity of somatotrophic tumors (STs), intragroup differential diagnostics is of practical importance, since it allows to predict scenario of acromegaly clinical course, as well as the efficacy of secondary drug therapy (DT).The aim of this study was to determine prognostic power of cytological, immunological&radiological predictors of sensitivity/resistance to fg-SRLs in patients with pure somatotropinomas.Materials and Met...