Endocrine Abstracts

Introduction: Adrenocorticotropic hormone (ACTH) is a tropic hormone produced by the anterior pituitary that stimulates the adrenal glands to release cortisol. The ACTH measurement is often used to diagnose the pituitary and/or adrenal disorders, mainly Cushing’s disease, Cushing’s syndrome, Addison’s disease and hypopituitarism. Therefore, the assessment of plasma ACTH concentration is a crucial step in the differential diagnosis of hypothalamic–pituitary&...

Introduction: Pheochromocytomas are rarely diagnosed in pregnancy. The consequences of pheochromocytoma during pregnancy can be devastating for both mother and fetus. Effective treatment requires an accurate and early diagnosis, but sometimes the tumor is diagnosed relatively late, so it is absolutely necessary to respond quickly and effectively.Purpose: The aim of our study is to describe a patient with a history of medullary thyroid cancer who underwen...

Introduction: Paragangliomas are rare neuroendocrine neoplasms arising from chromaffin cells in the sympathetic or parasympathetic neural paraganglia that may appear in many places throughout the body. These might be benign or malignant tumors. We report an interesting case of disseminated paraganglioma, the diagnosis of which began with the metastasis to the thyroid gland.Case presentation: A 69-year-old patient with a history of toxic multinodular goit...

Introduction: The CHEK2 gene is involved in DNA repair. Germline mutations in the CHEK2 gene impair this mechanism, increasing the risk of various cancers, including papillary thyroid cancer (PTC). There are four different mutation variants in the CHEK2 gene in the Polish population: three truncating mutations (1100delC, IVS2+1G>A and del53950) and one missense mutation (I157T).Material: The study included 1,547 PTC patient...