ea0099p235 | Adrenal and Cardiovascular Endocrinology | ECE2024
Puygrenier Pierre
, Perlemoine Karine
, Ragazzon Bruno
, Jouinot Anne
, Stratakis Constantine
, Bertherat Jerome
, Berthon Annabel
The most frequent molecular alteration in adrenocortical tumors (ACT) is the activation of the Wnt/β-catenin pathway that is associated with poor prognosis in adrenocortical carcinoma. Activating β-catenin mutation (p.S31, p.S37, p.S45, T.41) inhibiting its proteosomal degradation by the canonical destruction complex is responsible for its abnormal activation in roughly 30% of ACT. However, the E3 ubiquitin protein ligase 1, SIAH1 is able to ubiquitinate β-caten...