ea0014s15.4 | Novel bone hormones and regulators | ECE2007
R Williams Graham
Childhood hypothyroidism results in severely delayed skeletal development whereas adult thyrotoxicosis is associated with a 34 fold increase in osteoporotic fracture. To investigate molecular mechanisms underlying these abnormalities we characterized the skeletal phenotypes of mice harboring dominant negative mutations (TRα1PV/+, TRα1R384C/+, TRβPV/PV) or deletions (TRα0/0, TRβ−/−) of the genes encoding TRα and TRβ. Endochon...