Endocrine Abstracts

Background: Programmed disruption of the methionine cycle elevates plasma homocysteine concentrations leading to cardiovascular disease (CVD). Elements of this cycle are glucocorticoid responsive. Here we measured plasma cortisol, cysteine, homocysteine, glutathione and its breakdown product cysteinyl-glycine in the fed and fasted state in sheep....

Aim: To analyze the safety, efficacy and dosimetry of Lu-177 labeled prostate specific membrane antigen (PSMA) ligand 617 in patients with progressive metastatic castration-resistant prostate cancer (mCRPC), in comparison with Lu-177 PSMA I&T.Methods: Lu-177 PSMA-617 radioligand therapy (PRLT) was performed in 64 mCRPC patients. The median administered activity per treatment was 6 GBq. Ga-68 PSMA PET/CT was used for patient selection and follow-up. H...

Background: Serum thyroglobulin (Tg) measurements are one of the main pillars of thyroid cancer follow-up, because of the high organ and disease specificity of Tg in athyrotic patients. However, 20–25% of patients have detectable serum anti-Tg auto-antibodies (TgAB), which might cause false low Tg measurements in immunometric assays (IMA). This can lead to significant challenges in patient management. Measurement of Tg by liquid chromatography-tandem mass spectrometry (LC...

Background: Phaeochromocytomas (PC) are rare tumours of chromaffin cells which may present with relatively common and non-specific symptomatology. The optimal biochemical investigation to confirm or refute the diagnosis remains unclear; some centres use fractionated plasma metanephrines, which are very sensitive but lack specificity, while others use conventional measurements of urinary metanephrines, which may be affected by concurrent drug administration and are less sensiti...