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ea0050oc5.4 | Reproduction and Neuroendocrinology | SFEBES2017

Reactive oxygen species as a novel metabolic pathway for sperm DNA damage and Recurrent Pregnancy Loss

Radia Utsav K , Jayasena Channa N , Figueiredo Monica , Revill Larissa Franklin , Dimakopoulou Anastasia , Osagie Maria , Vessey Wayne , Regan Lesley , Rai Rajendra , Dhillo Waljit S

Background: Recurrent pregnancy loss (RPL) affects 12% couples, and is defined as ≧3 consecutive pregnancy losses before 20-weeks gestation. RPL is caused by foetal chromosomal abnormalities, or maternal factors such as thrombophilia. It was recently reported that men with RPL have high levels of sperm DNA fragmentation (a marker of infertility); however, the cause of this damage is currently not known. Seminal plasma has high levels of granulocyte-derived o...

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ea0050oc5.4 | Reproduction and Neuroendocrinology | SFEBES2017

Reactive oxygen species as a novel metabolic pathway for sperm DNA damage and Recurrent Pregnancy Loss

Radia Utsav K , Jayasena Channa N , Figueiredo Monica , Revill Larissa Franklin , Dimakopoulou Anastasia , Osagie Maria , Vessey Wayne , Regan Lesley , Rai Rajendra , Dhillo Waljit S

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Endocrine Abstracts

Reactive oxygen species as a novel metabolic pathway for sperm DNA damage and Recurrent Pregnancy Loss

Reactive oxygen species as a novel metabolic pathway for sperm DNA damage and Recurrent Pregnancy Loss

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