Endocrine Abstracts

Introduction: Pituitary metastases account for approximately 1% of pituitary lesions, most frequently originating from lung or breast cancer. We describe a case of a pituitary metastasis from colon cancer, a rare origin.Case report: a 36 year-old male, previously healthy, came to the emergency department for new onset jaundice and fever. He also had headaches for the last 3 months, and for the last month diplopia, left palpebral ptosis and low libido. Ph...

Introduction: Deficiency of 11-beta hydroxylase (11-HD) accounts for 5% of the causes of congenital adrenal hyperplasia (CAH), with an incidence of 1:100,000. The classic form phenotype consists in an excess of androgens and mineralocorticoids, which clinically translates into hypertension and hypokalaemia. In boys, there may be an increase in penis size, early adrenarche, increased growth velocity, and advancing bone age.Clinical case: We present a case...

Introduction: Type 1 diabetes mellitus (DM1) is frequently associated with other autoimmune diseases. Among children and adolescents, thyroid disease is the most common autoimmune endocrinopathy. The possibility of occult thyroid disease should be considered at diagnosis and when a patient is assessed at the annual review.Objective: The aim of our study was to determine the prevalence of autoimmune thyroiditis among children and adolescents with type 1 d...

Treatment for osteoporosis in children/adolescents is extremely important not only to improve bone quality but also because, if left untreated, could lead to severe and precocious loss of bone mass. Studies in growth hormone (GH) deficient adults, in turn, have shown that treatment with GH produce bone mass gain and improve the occurrence of both bone formation and reabsorption.The authors present the following case report of a 16 year old Caucasian fema...

Introduction: Multiple pituitary adenomas (PA) have a prevalence of 0.2-2.6% of all resected PAs. However, most of them are simultaneously diagnosed and in the setting of acromegaly. In a 2019 surgical series with 22 cases of multiple PAs, only one case was asynchronous and all of them had a positive immunohistochemical staining.Case report: A 32-year-old woman (1996) was referred to na Endocrinology appointment with amenorrhea and weight gain for the la...

Paediatric Graves’ disease (PGD) is an uncommon autoimmune disorder with a multifactorial origin. Although, in some autoimmune endocrinophaties the seasonality of month of birth (MOB) distribution differed from the general population, this association has not been study in PGD. The aim of this work was to analyse the impact of seasonality of MOB on PGD incidence in Portugal.In 2013, the Portuguese Paediatric Society of Diabetes and Endocrinology und...

Aim: Dose corrected for thyroid gland size is one of the methods used to determine radioactive iodine (RAI) activity for patients with Graves disease (GD). This study was aimed to investigate the real-world success rate of this method and the predictors of success after first treatment.Methods: This is a retrospective study of 80 patients with GD treated between 2014 and 2020 in a tertiary referral hospital in Almada, Portugal. The successful group was d...

Thyroid storm (TS) is one extreme of a continuum beginning with thyrotoxicosis. It’s rarely caused by exogenous thyroid hormone intake (ETHI). Aggressive medical therapy is the cornerstone of treatment; nevertheless, it might not be sufficient. Plasmapheresis is an extracorporeal technique that can rapidly lower thyroid hormone levels. The aim of this study was to assess the efficacy of plasmapheresis in TS secondary to ETHI. We evaluated retrospectively all TS cases (Bur...

Introduction: Pheochromocytomas (PHEO) and paragangliomas (PGL) are rare catecholamine-secreting tumors. Some authors proposed that there is a positive linear relationship between tumor size and measurements of metanephrines and an absence of association with catecholamine levels.Objectives: To review and characterize patients diagnosed with PHEO and PGL in Garcia de Orta Hospital. To determine the relationship between tumor size and measurements of urin...

Introduction: Multiple endocrine neoplasia (MEN) is a rare genetic syndrome characterized by occurrence of tumors involving two or more endocrine glands. Four types are described: MEN1, MEN2, MEN3 and the recently identi&#-1279;ed MEN4. Due to the complexity of the syndromes, it is difficult to manage these patients. Our objective was to describe the clinical features of individuals from 7 families with a diagnosis of MEN1 or MEN2 and identify current challenges in clinical pr...