ea0032p690 | Neuroendocrinology | ECE2013
Steffani Liliana
, Nitto Francesca Di
, Macchi Chiara
, Dongiovanni Paola
, Rametta Raffaella
, Valenti Luca Vittorio
, Fargion Silvia
, Magni Paolo
, Ruscica Massimiliano
Iron represents a micronutrient for cellular metabolism and aerobic respiration, and is essential for proper brain development in the fetal and early neonatal period. However, excess iron produces toxic build-up via free radical formation. In thalassaemic and juvenile hemochromatosis patients with pubertal failure, iron overload interferes with the correct function of the hypothalamic–pituitary axis, leading to hypogonadotrophic hypogonadism and growth failure, but the me...