Endocrine Abstracts

Introduction: In Romania universal salt iodization was implemented into practice since 2002, and iodine content of salt was gradually increased afterward. The efficiency and sustainability of this nationwide program were evaluated among school children from endemic regions of Mures and Harghita Counties. During these studies thyroid ultrasound characteristic for chronic autoimmune thyroiditis was observed in a considerable number of cases.Objective: To e...

We report the case of a 25-year-old woman (K.Cs.) hospitalized in our clinic for endocrinological investigation, presenting a spontaneous abortion 3 weeks before hospitalization. From medical history, we mention a cerebral thrombophlebitis with intracranian hypertension syndrome, appeared after oral contraceptive drug (Diane 35R) used for 5 months. The clinically asymptomatic patient presented diffuse goiter (I. gr.), overweight and virilism, without other clinical ...

Objective: The latest studies on Graves’ ophthalmopathy (GO) emphasize the importance of the orbital adipose tissue and fibroblasts in the pathogenesis of the disease by secreting proinflammatory cytokines. In vitro, these cytokines were proved to have a major role in the maintenance and progress of inflammation in the orbit. The aim of this study was to investigate serum cytokine levels in patients with GO.Materials and methods: Serum interl...

Introduction: Medullary thyroid carcinoma (MTC) in multiple endocrine neoplasia type 2B (MEN2B) syndrome is associated with RET mutation. Patients harbouring de novo mutations are usually diagnosed in more advanced stages of the disease. We present the case of a young female patient with MEN2B diagnosed with stage IV medullary thyroid carcinoma at the age of 10 years.Aim: Characterizing the efficacy of the different sequences of therapies and disease pro...

Introduction: Medullary thyroid cancer (MTC) is a rare thyroid neoplasm arising from parafollicular C-cells secreting calcitonin. Although it possesses specific histological and biochemical markers, real-life diagnosis and management remain challenging.Aim: A retrospective analysis of MTC patients from four Hungarian endocrine university centres over 23 years (2000-2023) was undertaken. Demographic data and biochemical markers, staging, germ-line RET mut...