Endocrine Abstracts

Introduction: Adrenal Insufficiency (AI) is a heterogeneous condition comprising primary, secondary and tertiary disease. Individuals with AI suffer more frequent infections and take longer to recover. Adrenal Crises (ACs), most commonly precipitated by infections, are an acute life-threatening complication with a reported mortality of 6%. ACs are, at least in part, potentially preventable and outcomes are improved by early initiation of high-dose glucocorticoids. Currently, t...

Introduction: An increasing notion suggests that aldosterone contributes to the development and progression of atherosclerosis and cardiovascular disease. Experimental studies documented an upregulation of cellular adhesion molecules, which are involved in the pathogenesis of atherosclerosis, after administration of aldosterone. However, evidence for an association between circulating aldosterone levels and soluble cellular adhesion molecules in humans is sparse.<p class="...

Over the past several years, growing evidence suggested that serum cortisol is associated with increased cardiovascular (CVD) mortality in patients with chronic heart failure. The prognostic significance of serum cortisol concentration (SCC) in patients with acute coronary syndrome (ACS) however is unknown.In the prospective Ludwigshafen Risk and Cardiovascular Health (LURIC) study 3316 patients (median age: 63.5 (56.3–70.6) years; 30.2% women) were...

In foetuses at risk of virilising CAH, prenatal treatment can be offered by administration of dexamethasone (DEX) via the mother in order to prevent genital malformations. Accumulating evidence from animal studies and epidemiological data raise concerns regarding the long term consequences of excess glucocorticoids on the developing foetus. The European study PREDEX is organized as an open, controlled, non-randomised, multicentre trial. The impact of DEX on the general well-be...

Reputedly, thyroid hormones make thinner and change the body composition. The aim of this randomized and prospective study was the assessment of the effect of levothyroxine suppressive therapy on body composition in women with benign thyroid nodule.Method: Thirty seven euthyroid and non obese women (18–60 years old) with benign thyroid nodule (fine needle cytology and calcitonin measurement) were randomized into 2 equal groups. The first group recei...