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ea0029oc18.4 | Paediatric Endocrinology | ICEECE2012

Mortality in GH-treated (Tx) patients (pts) enrolled in the global genetics and neuroendocrinology of short stature international study (GeNeSIS)

Child C. , Zimmermann A. , Quigley C. , Rosenfeld R. , Robison L. , Blum W.

Preliminary data from the French SAGhE study of 6928 pts with isolated idiopathic GH deficiency (IsIGHD), idiopathic short stature (ISS) or born small for gestational age (SGA) who started GH treatment during childhood (19851996) & were followed up in 2009, suggested increased mortality vs the French general population (pop; standardized mortality ratio (SMR): 1.3, 95% confidence interval (CI): 1.11.6; 116 403 person-years (PY))1.<p class="abstex...

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ea0029p1434 | Pituitary Clinical | ICEECE2012

Mortality rates in childhood and adult onset GH deficient patients enrolled in the Global Hypopituitary Control and Complications Study (HypoCCS)

Jung H. , Zimmermann A. , Mo D. , Robison L. , Erfurth E. , Melmed S. , Lamberts S. , Attanasio A.

Preliminary data suggested an increased mortality in a French cohort after childhood somatropin treatment compared to the French reference population1. This cohort included patients (pts) with idiopathic-isolated GH-deficiency (GHD), and a similar cohort is also under follow-up for adult GH-replacement in HypoCCS.We therefore assessed all-cause mortality rates (n/1000 person-years (PY), (95% CI), standardized to the age/gender structure...

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Endocrine Abstracts

Mortality in GH-treated (Tx) patients (pts) enrolled in the global genetics and neuroendocrinology of short stature international study (GeNeSIS)

Mortality rates in childhood and adult onset GH deficient patients enrolled in the Global Hypopituitary Control and Complications Study (HypoCCS)

BiosciAbstracts