Searchable abstracts of presentations at key conferences in endocrinology

ea0031s2.1 | Hormone Maketh Man | SFEBES2013

Anti-Mullerian hormone: a Sertoli cell hormone that can be used as a predictor of male hypogonadism

Rey Rodolfo

Sertoli cells are the most active cell population in the prepubertal testis. During infancy and childhood, male hypogonadism can be evidenced by assessing Sertoli cell function without the need for stimulation tests. Anti-Müllerian hormone (AMH) is a distinctive serum marker of the prepubertal Sertoli cell, which is high from foetal life until puberty. AMH production is stimulated by FSH and potently inhibited by androgens. Initially used only to distinguish between patie...

ea0032p645 | Male reproduction | ECE2013

Prenatal testosterone programming: ontogeny of changes in testis of fetal and prepubertal male sheep

Rojas-Garcia Pedro Pablo , Recabarren Monica Patricia , Sandoval Daniel , Carrasco Albert , Fornes Romina , Rey Rodolfo , Sir-Petermann Teresa , Recabarren Sergio E

The reprogramming effects of an excess of testosterone during pregnancy in males born to PCOS mothers as well as in animal models for PCOS has been only recently evaluated. We have found in a sheep model of PCOS that prenatal T (PT) excess impact on the testis of adults with increased Sertoli cell (SC) number, decreased sperm count, and reduced germ cell (GC) number. The ontogeny of such disruptions and the mechanisms have not been established. This study addressed the impact ...

ea0103p108 | Gonadal, DSD and Reproduction 2 | BSPED2024

Towards best practice therapies for patients with gonadotropin deficiency in minipuberty and puberty

Castro Sebastian , Laurer Elisabeth , Varughese Rachel , Bryce Jillian , Ahmed Faisal , Rey Rodolfo , Hogler Wolfgang , Heger Sabine , Nordenstrom Anna , Rohayem Julia , Howard Sasha

Gonadotropin deficiency, secondary either to hypogonadotropic hypogonadism with hypothalamic gonadotropin-releasing hormone (GnRH) deficiency, or to combined pituitary hormone deficiency, is a rare condition where even expert centres manage only small numbers of patients each year. Best practice therapies are not clearly defined, although the case for supporting replacement of combined gonadotropins - in infancy to replace minipuberty and in adolescence to replace puberty - in...

ea0059p181 | Reproduction | SFEBES2018

Gonadectomy for adults with DSD conditions at risk of hypogonadism in the international disorders of sex development registry

Herald Angela Lucas , Kyriakou Andreas , Bryce Jillian , Rodie Martina , Acerini Carlo , Arlt Wiebke , Balsamo Antonio , Baronico Federico , Bertelloni Silvano , Brooke Antonia , van der Grinten Hedi Claahsen , Cools Martine , Darendeliler Feyza , Davies Justin H , Desloovere An , Ellaithi Mona , Fica Simona , Gawlik Aneta , Guran Tulay , Hannema Sabine , Hiort Olaf , Holterhus Paul-Martin , Iotova Violeta , Jennane Farida , Lachlan Katherine , Li Dejun , Lisa Lidka , Mazen Inas , Mladenov Wilchelm , Mohnike Klaus , Nedelea Lavnia , Niedziela Marek , Nordenstrom Anna , Poyrazoglu Sukran , Rey Rodolfo , Tadokoro-Cuccaro Rieko , Weintrob Naomi , Ahmed Syed Faisal

Introduction: Disorders of Sex Development (DSD) can be associated with an increased risk of germ cell tumours depending on the underlying diagnosis. To date however knowledge regarding the indications and timing of gonadectomy is lacking.Methods: The I-DSD Registry was interrogated for anonymised information regarding the diagnosis, karyotype, sex of rearing and timing of gonadectomy, if undertaken, of all individuals of any karyotype who were over the ...

ea0103oc5.5 | Endocrine Oral Communications 1 | BSPED2024

Glucocorticoid replacement therapy in congenital adrenal hyperplasia and its associations with growth outcomes - real world data analysis from an international cohort of 1500 patients

A Bacila Irina , Lawrence Neil R. , Balagamage Chamila , Bryce Jillian , Ali Salma R. , Alimussina Malika , Chen Minglu , Arya Ved Bhushan. , Atapattu Navoda , Bachega Tania , Barat Pascal , Baronio Federico , Bertelloni Silvano , Birkebaek Niels , Bonfig Walter , Bruin Christiaan de. , - van der Grinten Hedi Claahsen. , Cools Martine , Costa Eduardo , Crowne Elizabeth , Davies Justin H. , Debono Miguel , Vries Liat de. , Kubat Katja Dumic. , Elsedfy Heba , Evliyaoglu Olcay , Flueck Christa , Gazdagh Gabriella , German Alina , Gevers Evelien F. , Globa Evgenia , Guran Tulay , Guven Ayla , Guazzarotti Laura , Hannema Sabine , Hatipoglu Nihal , Janus Dominika , Kamp Hetty van. de. , Karabouta Zacharoula , Krone Ruth E. , Leka-Emiri Sofia , Taube Nina Lenherr. , Lichiardopol Corina , Hassan Mona Mamdouh. , Marginean Otilia , Markosyan Renata , Mazen Inas , Miles Harriet , Mitchell Anna L. , Mohnike Klaus , Neumann Uta , Niedziela Marek , Nordenstrom Anna , O'Connell Susan M. , Phan-Hug Franziska , Poyrazoglu Sukran , Probst-Scheidegger Ursina , Rey Rodolfo , Russo Gianni , Salerno Mariacarolina , Sanctis Luisa de. , Seneviratne Sumudu N. , Segev-Becker Anat , Shenoy Savitha , Skae Mars , Thankamony Ajay , Ucar Ahmet , Utari Agustini , Vieites Ana , Wasniewska Malgorzata , Ahmed S Faisal. , Krone Nils P.

Background and Aim: Previous research using data from the I-CAH registry showed wide variation between countries in the provision of glucocorticoid (GC) replacement in congenital adrenal hyperplasia (CAH). In this study, we aimed to establish the impact of different GC doses on height and weight in children and young people with CAH.Methods: Data from children with CAH recorded in the I-CAH registry since 2003 was collected, providing a cohort of 1522 pa...