Endocrine Abstracts

Sertoli cells are the most active cell population in the prepubertal testis. During infancy and childhood, male hypogonadism can be evidenced by assessing Sertoli cell function without the need for stimulation tests. Anti-Müllerian hormone (AMH) is a distinctive serum marker of the prepubertal Sertoli cell, which is high from foetal life until puberty. AMH production is stimulated by FSH and potently inhibited by androgens. Initially used only to distinguish between patie...

The reprogramming effects of an excess of testosterone during pregnancy in males born to PCOS mothers as well as in animal models for PCOS has been only recently evaluated. We have found in a sheep model of PCOS that prenatal T (PT) excess impact on the testis of adults with increased Sertoli cell (SC) number, decreased sperm count, and reduced germ cell (GC) number. The ontogeny of such disruptions and the mechanisms have not been established. This study addressed the impact ...

Gonadotropin deficiency, secondary either to hypogonadotropic hypogonadism with hypothalamic gonadotropin-releasing hormone (GnRH) deficiency, or to combined pituitary hormone deficiency, is a rare condition where even expert centres manage only small numbers of patients each year. Best practice therapies are not clearly defined, although the case for supporting replacement of combined gonadotropins - in infancy to replace minipuberty and in adolescence to replace puberty - in...

Introduction: Disorders of Sex Development (DSD) can be associated with an increased risk of germ cell tumours depending on the underlying diagnosis. To date however knowledge regarding the indications and timing of gonadectomy is lacking.Methods: The I-DSD Registry was interrogated for anonymised information regarding the diagnosis, karyotype, sex of rearing and timing of gonadectomy, if undertaken, of all individuals of any karyotype who were over the ...

Background and Aim: Previous research using data from the I-CAH registry showed wide variation between countries in the provision of glucocorticoid (GC) replacement in congenital adrenal hyperplasia (CAH). In this study, we aimed to establish the impact of different GC doses on height and weight in children and young people with CAH.Methods: Data from children with CAH recorded in the I-CAH registry since 2003 was collected, providing a cohort of 1522 pa...