ea0065oc6.1 | Reproductive Endocrinology and Biology | SFEBES2019
Abbara Ali
, Duijkers Ingrid
, Ezzati Max
, Voors Christine
, Romeijn Christel
, Berman Lance
, Fan Xiaolin
, Migoya Elizabeth
, Dhillo Waljit S
Background: Kisspeptin is an endogenous neuropeptide that regulates GnRH release from the hypothalamus. Kisspeptin-54 has been shown to effectively trigger oocyte maturation during in vitro fertilisation (IVF) treatment, but with markedly reduced rates of ovarian hyperstimulation syndrome (OHSS). The kisspeptin receptor agonist, MVT-602, has a longer half-life than native kisspeptin-54 (1.52.2 h vs. 0.5 h) and has potential for development as a novel trigger of oocyte ma...