Endocrine Abstracts

Background: Clinically severe or recurrent subacute thyroiditis (SAT) frequently requires treatment with high cumulative doses of systemic steroids. Such therapy is associated with high risk of steroid-related complications. The DLISAT study aims to evaluate the efficacy and safety of intrathyroidal dexamethasone and lidocaine injections (DLI) in specific patient cohorts compared to standard oral steroid therapy. This report presents preliminary results after the initial six m...

Introduction: Medullary thyroid cancer (MTC) is a well-differentiated neuroendocrine tumor in which somatostatin receptor (sst) expression is higher for sst1 and sst5 than for sst2. This may explain why the available sst2–selective analogues do not work in these patients and why pasireotide (SOM230), a novel, multi-receptor targeted somatostatin analogue with high-binding affinity for sst1,2,3 and sst5 coul...