ea0041ep591 | Endocrine tumours and neoplasia | ECE2016
Falletta Simona
, Partelli Stefano
, Rubini Corrado
, Nann Dominik
, Doria Andrea
, Marinoni Ilaria
, Polenta Vanessa
, Di Paquale Carmelina
, Uberti Ettore Degli
, Perren Aurel
, Falconi Massimo
, Zatelli Maria Chiara
Introduction: Medical therapy of Pancreatic neuroendocrine tumors (P-NETs) may take advantage from mammalian target of rapamycin (mTOR) inhibitors. However, so far, the extent of therapeutic response cannot be predicted.Aim: To investigate the possible predictors of sensitivity to mTOR inhibitors in P-NETs.Materials and methods: P-NET primary cultures were treated with IGF1 and/or Everolimus. Cell viability and caspase activity wer...