Endocrine Abstracts

Introduction: Although widely prescribed, the benefit of thyroid hormone replacement in subclinical hypothyroidism (SHypo) is unclear. We performed a systematic review and meta-analysis of randomized controlled trails (RCTs) to assess the impact of thyroid hormone therapy on clinical outcomes.Methods: We followed the PRISMA guidelines and registered the study protocol on PROSPERO (CRD42017055536). We searched PubMed, Embase, Web of Science, COCHRANE Libr...

Background and aims: Diabetic ketoacidosis is acute complication of diabetes mellitus. Hyperglycemia is one of the diagnostic features of diabetic ketoacidosis. Electrolyte disturbances are common as well. Aim of this study is to examine whether there is a difference in serum glucose, sodium and potassium concentrations with respect to age, gender and severity of diabetic ketoacidosis.Materials and Methods: Medical records from 1 January 2017 to 31 Decem...

We have recently reported that somatic mutations in the ubiquitin-specific protease 8 (USP8) are present in corticotropinomas of patients with Cushing’s disease and that these mutations reduced the interaction with 14-3-3. Mutant USP8 exhibited higher deubiquitination activity and potentiated EGFR-induced POMC expression (Reincke et al., Nat Genet 2014). To further study the prevalence of these mutations, we have analyzed 134 ACTH-producing corticotropin...

Background and Objective: Thyroid function reference ranges are statistically defined by the 2.5th and 97.5th percentiles, which do not account for potential risk of clinical outcomes. We aimed to define the optimal ranges of thyroid-stimulating hormone (TSH) and free thyroxine (FT4), based on the risk of cardiovascular disease (CVD) and mortality.Methods: We performed an individual-participant data analysis and identified prospecti...