Endocrine Abstracts

Disruption of circadian regulation could trigger and exacerbate obesity, type 2 diabetes mellitus, and cardiovascular disease. Experiments on rats proved that the deleterious effects of chronodisruption are extremely severe, especially during early developmental stages. Only part of them could be prevented by maternal melatonin administration, suggesting that other pathophysiological mechanisms may be involved. To investigate the role of other mechanisms that might contribute ...