ea0070aep252 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020
Ojo Opeolu
, Ofosu Wendy
, Abiodun Falobi Ayodele
, Benjamin Falana Ayokunle
, Sen Monica
, Smyth Lesley
Aim: Our previousstudies have shown evidence for insulin-releasing actions of some amphibian skin peptides; including esculentin-2CHa. However, there is a need to further improve the potency of some of this peptides and to characterize their other beneficial effects. This study investigates the effect of a Leu31→Lys substitution on the insulin-releasing and immunomodulatory effects of esculentin-2CHa.Methods: BRIN-BD11 cells were incubat...