ea0029p307 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012
Kuwahara K.
, Minami T.
, Shibata J.
, Yamada C.
, Kuwabara Y.
, Nakao K.
Kinoshita H.
, Usami S.
, Nakagawa Y.
, Nishikimi T.
, Nakao K.
Myocardin-related transcription factor (MRTF)-A is a Rho signaling-responsive co-activator of serum response factor (SRF). In this study we investigated roles of MRTF-A in the process underlying vascular diseases by using two different mouse models of vascular diseases. MRTF-A expression was significantly higher in the wire-injured femoral arteries of wild-type mice and in the atherosclerotic aortic tissues of ApoE−/− mice than in healthy control tissues...