Endocrine Abstracts

Context: Hyponatremia is associated with an increased risk of osteoporosis and fractures, and in recent years increasing evidence is accumulating in favor of a likely causal relationship between hyponatremia and bone loss. In rat models, the induction of hyponatremia enhances osteoclast activation and bone catabolism. In humans, the correction of hyponatremia by tolvaptan or SGLT2-inhibitors has a favorable effect on bone turnover markers, possibly due to an interplay both wit...