ea0025p272 | Reproduction | SFEBES2011
Sleeth Michelle
, Beale Kylie
, Thompson Emily
, Baxter Jordan
, Bloom Stephen
, Murphy Kevin
Leptin is an adipocyte-derived cytokine critical to the integration of energy homeostasis and reproduction which putatively acts as a metabolic gate for the onset of puberty. However, it is unknown whether the age of puberty reflects leptin levels or leptin sensitivity. If pubertal age reflects leptin sensitivity, it may also reflect susceptibility to diet-induced obesity.We hypothesised that age of pubertal onset reflects leptin sensitivity. We assessed...