ea0037ep1188 | Clinical Cases–Pituitary/Adrenal | ECE2015
Lafuente Christian
, Arcano Karina
, Guerrero Fernando
, Marengo A
, Peiro I
, Soria Ainara
, Diez Juan Jose
, Villabona Carlos
, Iglesias Pedro
Context: Ipilimumab is a human monoclonal antibody against cytotoxic T lymphocyte antigen-4 (CTLA-4), which enhances stimulation of cytotoxic T lymphocytes, resulting in an immune response against the tumour. This drug-induced hyperactivity of the immune system can lead to serious adverse effects including endocrine disorders such as autoimmune hypophysitis, thyroiditis and adrenal insufficiency.Objective: To report our experience on ipilimumab-induced h...