Endocrine Abstracts

The spectrum of lesions in the sellar and parasellar region includes a wide range of diseases, from the most common adenoma to various non-adenomatous lesions i.a. empty sella syndrome, stroke and congenital conditions. We identified a case of meningitis in which the images initially suggested the presence of a pituitary macroadenoma. The 45-year-old patient without chronic diseases was admitted to the Department of Neurology due to severe headaches and vomiting that had woken...

Metastatic involvement of the pituitary gland is a rare phenomenon with various clinical and radiological manifestations, but it is clinically important and requires appropriate and early diagnosis. The posterior lobe of the pituitary gland is more often involved, so we expect that AVP deficiency would be the most common clinical manifestation of pituitary metastasis. Presentation without involvement of the posterior lobe, without AVP deficiency and with anterior lobe hypofunc...

Objective: The diagnosis of Cushing’s syndrome may be challenging, especially in cases of patients with chronic kidney disease (CKD).Aim: The assessment of late night salivary cortisol concentration, serum and salivary concentration in overnight dexamethasone suppression test in patients with CKD stage III–V and a control group.Patients and methods: 37 patients mean age 66±12 (M=13) with CKD stage III–V...

Objective: Growth hormone (GH) is used for metabolic indications in the treatment of adult patients with GH deficiency (GHD). In addition to influencing growth processes in childhood, GH is important in regulating metabolic processes at every stage of life. GH, via insulin-like growth factor (IGF-1), has an anabolic effect on protein metabolism, also in skeletal muscles and cardiac muscle. Moreover, myokines produced by muscle fibers stimulated by muscle contraction, acting in...

Background: Fatty acid desaturase 1 (FADS1) gene controls the fatty acid metabolism pathway in the human body (Sergeant et al., 2012). Single nucleotide polymorphism (SNP) in FADS1 gene and percentage of polyunsaturated fatty acids inserum lipids was associated (Klingel et al., 2018). Genetically predisposition to higher plasma arachidonic and stearic acid levels were associated with incidence oflarge-artery stroke and venous thromboembolism...