Endocrine Abstracts

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in reproductive-age women. This highly complex reproductive metabolic disorder is independently associated with high prevalence of non-alcoholic fatty liver disease (NAFLD). While the gold standard of NAFLD diagnosis is liver biopsy or MRI, it is costly and hard to perform in large population. Recently, simple and convenient markers, such as liver fat score (LFS), fatty liver inde...

Introduction: 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a dimeric enzyme that catalyzes the reduction of cortisone to cortisol within the endoplasmic reticulum. Loss of this activity results in a disorder termed cortisone reductase deficiency type 1 (CRD). Only mutations in H6PD gene, which encodes an enzyme supplying cofactor for the reaction, have been identified as the cause of disease. Biochemical features of CRD are increased cortisol clearance and A...