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Endocrine Abstracts

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ea0041ep777 | Obesity | ECE2016

A prostate cancer risk associated polymorphism regulates androgen mediated regulation of a novel long noncoding RNA, IRX4lncRNA

Panchadsaram Janaththani , Tevz Gregor , Stylianou Nataly , Hollier Brett , Nelson Colleen , Williams Elizabeth , Clements Judith , Batra Jyotsna

Prostate cancer (PCa) is the second most common cause of cancer death in developed countries. Our RNAseq analysis identified a novel long non-coding RNA, IRX4lncRNA at chromosome 5p15. The expression of IRX4lncRNA was much higher in prostate tumor samples (n=50) compared to their matched controls. Moreover, knockdown of lncRNA reduced the cell proliferation of LNCaP cells and this lncRNA was down-regulated in the cells undergoing Epithelial ...
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ea0099oc13.1 | Oral Communications 13: Late Breaking | ECE2024

BCL2 expression is enriched in androgen receptor-negative advanced prostate cancer:

Jimenez-Vacas Juan M , Westaby Daniel , Figueiredo Ines , Rekowski Jan , Pettinger Claire , Gurel Bora , Bogdan Denisa , Buroni Lorenzo , Neeb Antje , Padilha Ana , Taylor Joe , Zeng Wanting , Das Souvik , Hobern Emily , Riisnaes Ruth , Crespo Mateus , Miranda Susana , Ferreira Ana , Hanratty Brian , Nava Rodrigues Daniel , Bertan Claudia , Seed George , Fenor de La Maza Maria de Los Dolores , Guo Christina , Carmichael Juliet , Grochot Rafael , Chandran Khobe , Stavridi Anastasia , Varkaris Andreas , Stylianou Nataly , Hollier Brett , Tunariu Nina , Balk Steven , Carreira Suzanne , Yuan Wei , Nelson Peter , Corey Eva , Haffner Michael , de Bono Johann , Sharp Adam

Background: Treatment resistance in prostate cancer can be the result of multiple different tumour cell adaptations generating castration-resistant prostate cancer (CRPC). Despite advancements in treatment, CRPC remains a highly lethal disease. Some CRPCs become AR independent with loss of AR expression and lineage plasticity, urgently requiring novel therapeutic strategies. BCL2 can be upregulated in some CRPCs and may be a therapeutic target for this disease subset.<p cl...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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