ea0056oc9.2 | Thyroid from basics to clinics | ECE2018
Cho Sun Wook
, Shin Hyo Sik
, Sun Hyun Jin
, Park Young Joo
, Yi Ka Hee
Background: Metformin plays anti-tumoral roles in human cancers including breast and thyroid. However, its effects on metastatic lesions are undetermined. We studied the effects of metformin on bone metastasis of thyroid cancer.Method: Luciferase-tagged anaplastic FRO and follicular FTC 133 thyroid cancer cells were used. In vivo effects of metformin were evaluated in both ectopic tumor model and bone metastasis model generated by intratibial injection.<...