ea0090p351 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023
Pereira Sara C.
, Freire-Brito Lais
, Guerra-Carvalho Barbara
, Carrageta David F.
, Bernardino Raquel
, Crisostomo Luis
, Terzo Simona
, Monteiro Mariana P.
, Oliveira Pedro F.
, Allegra Mario
, Alves Marco
Metabolic and endocrine dysregulation induced by high-fat diet (HFD) can lead to decreased male fertility potential and have a negative impact on the offsprings metabolic health. Small non-coding RNAs (sncRNAs) were proposed as being potential mediators of metabolic queues across transgenerational inheritance. During development and epidydimal transit, spermatozoa become enriched with tRNA-derived stress-induced RNAs (tiRNAs). This sncRNAs class appears to be particularl...