ea0034oc3.1 | Steroids | SFEBES2014
Morgan Stuart
, McCabe Emma
, Gathercole Laura
, Hassan-Smith Zaki
, Larner Dean
, Bujalska Iwona
, Stewart Paul
, Tominson Jeremy
, Lavery Gareth
Glucocorticoids are widely prescribed for their anti-inflammatory properties, but have a significant adverse effect profile, leading to a Cushingoid phenotype. In the present study, we test the hypothesis that reactivation of glucocorticoids, in peripheral tissues by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), is a major determinant of exogenous Cushings syndrome.WT, global 11β-HSD1 knockout (GKO), liver-specific 11β-HSD...