Endocrine Abstracts

The antihyperglycaemic drug metformin reduces food consumption through mechanisms that are not fully elucidated. The present study investigated the effects of intracerebroventricular administration of metformin on food intake and hypothalamic appetite-regulating signalling pathways induced by the orexigenic peptide ghrelin. Rats were injected intracerebroventricularly with ghrelin (5 μg), metformin (50, 100 or 200 μg), AICAR (25 μg) and L-leucine (1 μg) in ...