Endocrine Abstracts

Background: Type III hyperlipidaemia (T3HL) is characterised by equimolar increases in plasma triglyceride and cholesterol on an APOE2/2 genotype background and conveys a high risk of early-onset cardiovascular disease (CVD). Phenotypic penetrance of T3HL is <10% and precipitated by several endocrine/metabolic disorders such as obesity, diabetes and hypothyroidism. We explored the effect of triglyceride-raising polygenic score precipitating T3HL, in the context of...

Background: The genotyped Mexico City Prospective Study (MCPS) cohort enables the causal effects of adiposity on lipids to be explored in an overweight Hispanic population with scarce statin use.Methods: MCPS participants aged 35-84 years, with baseline nuclear magnetic resonance measurements of blood lipids, and not using lipid-lowering therapy at recruitment were included. Using the Mendelian randomisation one-sample ratio method, univariable and multi...