Endocrine Abstracts

Exercise training and liraglutide have been shown to be effective in promoting weight loss, improving glycemic control, and regulating blood lipid levels, especially in animal models and patients with obesity and diabetes. However, their combined effects on body composition, glucose, and lipid metabolism in healthy aging models have not been studied yet. In this study, we used apparently healthy middle-aged (16-month-old) female Wistar rats that underwent ovariectomy (Ovx) to ...

Thyroid C-cells, as a second type of endocrine cell population within thyroid, produce and secrete peptide hormone calcitonin (CT). This hypocalcemic hormone acts as an inhibitor of bone resorption. The aging is a complex process that alters various cellular functions. Therefore, the aim of this study was to examine the aging-related changes in the structure and function of CT-producing thyroid C-cells in male Wistar rats, using histomorphometric, ultrastructural and biochemic...

Aging process is accompanied by structural and functional changes in different organs including bone and muscle tissues. Between these tissues there is a mutual interaction mediated by endocrine factors such as the peptide hormone osteocalcin, produced by osteoblasts. Since the skeletal muscles is composed of two basic fiber types, slow-twitch (type I) and fast-twitch (type II), the aim of this study was to examine the age-related changes in rat fast-twitch skeletal muscle fib...