ea0038oc4.3 | Diabetes and cardiometabolic complications | SFEBES2015
Gastaldello Annalisa
, Livingstone Dawn E
, Tsang Nicola
, Walker Brian R
, Hadoke Patrick W
, Andrew Ruth
Background: The 5α-reduced glucocorticoid, 5α-tetrahydrocorticosterone (5α-THB), displays a dissociated steroid profile exhibiting anti-inflammatory effects in a murine model of thioglycollate-induced peritonitis but failing to induce adverse metabolic effects caused by corticosterone. We assessed the topical anti-inflammatory properties of 5α-THB in a model of irritant dermatitis. Given the adverse effects of steroids on cutaneous wound healing, we also in...