ea0035p198 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014
Takeda Yoshiyu
, Wang Fen
, Demura Masashi
, Yoneda Takashi
, Karashima Shigehiro
, Cheng Yuan
, Kometani Mitsuhiro
, Ohe Masashi
The activation of local renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in the overall pathophysiology of the cardiovascular diseases. We have reported increased mRNA levels of angiotensinogen, angiotensin converting enzyme (ACE) and CYP11B2 (aldosterone synthase gene) in the heart of salt-sensitive hypertensive rats complicated with cardiac hypertrophy. However, the mechanism of control of gene expression of each component of RAAS gene in the heart is unknown...